RoseTTAFold2 is a three-track folding tool, which also handles multimer!
- inputs: amino acid sequence + CHEMICAL structure (WOAH! how?)
- “RF2 all-atom embedding”
- fold!
The model does really well!
application: de-novo luciferase design
- come up with the correct shaped scaffolds
- use old Rosetta to jam a residue sequence into the scaffold
- refold
application: RoseTTAFold2 in-painting
Train the model to recover the missing bits of sequence from the overall structure (i.e. training backwards), and